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目的探讨高血压患者脉压变化对尿微量白蛋白(UmALB)排泌量的影响。方法选取160例原发性高血压患者,根据脉压(PP)水平分成PP<70mmHg组,77例和PP≥70mmHg组,83例,两组均行系统降压治疗1月,将血压达标(BP140/90mmHg)者再继续治疗观察5月,分析这些患者治疗前后PP及UmALB的变化,并进行比较。结果PP<70mmHg组治疗前后UmALB量无明显改变。PP≥70mmHg组治疗后有60例血压达标,该组总的UmALB分泌量减少,其中治疗后PP<70mmHg病例比治疗后PP≥70mmHg病例的UmALB分泌量明显减少(P<0.05)。结论高血压患者随着脉压变化可引起UmALB排泌量的变化,PP从≥70mmHg降至PP<70mmHg时UmALB排泌量显著下降。
Objective To investigate the effect of pulse pressure on urinary albumin (UmALB) excretion in hypertensive patients. Methods 160 patients with essential hypertension were divided into two groups according to pulse pressure (PP): PP <70mmHg group, 77 cases and PP≥70mmHg group, 83 cases. Both groups were treated with systemic antihypertensive treatment for 1 month, BP140 / 90mmHg) were continued treatment observed in May, analysis of these patients before and after treatment PP and UmALB changes, and compared. Results There was no significant change in the amount of UmALB in PP <70mmHg group before and after treatment. In PP≥70mmHg group, 60 cases of blood pressure reached the standard, and the total UmALB secretion in this group decreased. The secretion of UmALB in patients with PP <70mmHg was significantly lower than that in PP≥70mmHg after treatment (P <0.05). Conclusions The changes of UmALB excretion can be caused by changes of pulse pressure in patients with hypertension. The excretion of UmALB decreased significantly when PP decreased from ≥70mmHg to PP <70mmHg.