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目的研究IFN＋2-2-1程序和2-2-1程序应用的可行性，探讨IFN的免疫调节作用。方法IFN＋2-2-1程序：于0、7、14天分别注射5．0、5．0、2．5IUPHKCV，于0天同时加注20万IUα-IFN；2-2-1程序：于0、7、14天分别注射5．0、50、2．5IUPHKCV；对照：应用WHO推荐的常规程序。结果①3种程序免疫后的GWT：7天时分别为1．71、1．57、1．21（P＜0．05）；14天时分别为62．77、58．79、28．36（P＜0．01）；45天时分别为76．64、72．90、62．77。②各组的阳转率：7天时分别为55．00％、33．3％、20．00％（P＜0．05）；14天时全部达到100％。③各组的各种副反应发生率（在0～55％之间）均无显著性差别。结论小剂量的IFN有增强免疫应答的作用；首次免疫时用双倍剂量的疫苗有显著的高免疫应答效应；IFN＋2-2-1程序优于2-2-1程序，后者又优于常规程序。
Objective To study the feasibility of IFN + 2-2-1 program and 2-2-1 program to investigate the immunomodulatory effect of IFN. Methods IFN + 2-2-1 program: 5.0, 5.0, 2.5 IUPHKCV were injected on days 0, 7, and 14, and 200,000 IU alpha-IFN was added simultaneously on day 0. 2-2-1 Procedure: , Respectively, injected with 5.0,50,2.5 IUPHKCV on days 7 and 14. Control: The routine procedure recommended by the WHO was used. Results ① GWT after 3 kinds of immunization were 1.71, 1.57 and 1.21 respectively (P <0.05) at 7 days and 62.77, 58.79 and 28.36 respectively at 14 days (P < 0.01); 45 days were 76.64,72.90,62.77. ② The positive rate of each group was 55.00%, 33.3% and 20.00% respectively at 7 days (P <0.05), and reached 100% at 14 days. ③ The incidence of various side effects in each group (between 0 and 55%) showed no significant difference. Conclusions Small doses of IFN have an enhanced immune response; double vaccination at the time of first immunization has a markedly high immune response effect; IFN + 2-2-1 is superior to 2-2-1 and the latter is superior to conventional program.