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目的探讨胰岛素抵抗与痛风的关系。方法痛风患者57例,正常对照组40例,分别测定空腹血糖、胰岛素及血脂、血尿酸(UA),稳态模型(HOMA)计算胰岛素抵抗指数(IRI)。分析胰岛素抵抗与痛风患者的关系。结果高胰岛素血症发生率痛风组高于正常对照组(P<0·01),甘油三酯(TG)、低密度脂蛋白(LDL-C)及胰岛素抵抗指数痛风组高于正常对照组(P<0·05),HDL-C痛风组低于对照组(P<0·05)。痛风患者的Pearson相关分析结果示:IRI与年龄、体质指数(BMI)、TG、LDL-C、UA呈正相关(P<0·05或P<0·01),与HDL-C呈负相关(P<0·05)。以IRI为应变量,上述指标为自变量,对痛风组进行多元线性逐步回归分析,结果在α=0·05水平,进入回归方程的因素有BMI、UA、TG(P<0·01或P<0·05),提示BMI、UA、TG是痛风组IRI的独立危险因素。结论痛风患者存在明显的胰岛素抵抗。
Objective To investigate the relationship between insulin resistance and gout. Methods 57 cases of gout and 40 cases of normal control group were measured fasting blood glucose, insulin and serum lipids, UA, HOMA to calculate IRI. Analysis of insulin resistance and gout patients. Results The incidence of hyperinsulinemia was higher in the gout group than in the normal control group (P <0.01). The triglyceride (TG), low density lipoprotein (LDL-C) and insulin resistance index gout group were higher than those in the normal control group P <0.05), HDL-C gout group was lower than the control group (P <0.05). Pearson correlation analysis of gout patients showed that IRI was positively correlated with age, BMI, TG, LDL-C and UA (P <0.05 or P <0.01), and negatively correlated with HDL-C P <0 · 05). Taking IRI as the dependent variable and the above indexes as the independent variable, the multivariate linear stepwise regression analysis of gout group showed that at the level of α = 0.05, there are BMI, UA, TG (P <0.01 or P <0.05), suggesting that BMI, UA and TG were independent risk factors of IRI in gout group. Conclusion Gout patients have obvious insulin resistance.