弥漫大B细胞淋巴瘤(DLBCL)是非霍奇金淋巴瘤中的常见类型,在遗传学改变、免疫表型及基因表达谱分析等方面存在明显的异质性,本文就DLBCL遗传异质性方面作一综述,重点阐述疾病与染色体易位、关键肿瘤抑制基因的缺失、基因拷贝数改变的关系以及其基因表达谱分析。 Diffuse large B-cell lymphoma (DLBCL) is a common type of non-Hodgkin’s lymphoma and has obvious heterogeneity in genetic changes, immunophenotype and gene expression profiling. In this paper, DLBCL genetic heterogeneity For a review, the emphasis is placed on the relationship between disease and chromosomal translocations, the absence of key tumor suppressor genes, changes in gene copy number, and their gene expression profiling.