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目的探讨急性心肌梗死患者血清巨噬细胞炎症蛋白1α(MIP-1α)和C反应蛋白(CRP)水平的变化。方法选择急性心肌梗死患者56例(AMI组);同期健康体检者52例(CON组);抽血检测血清MIP-1α和CRP水平,比较两组间差异。结果AMI患者血清MIP-1α水平明显高于CON组(P<0.001);血清CRP水平也明显高于CON组(P<0.001)。结论MIP-1α和CRP对急性心肌梗死的发生发展起到重要作用。
Objective To investigate the changes of serum macrophage inflammatory protein 1α (MIP-1α) and C-reactive protein (CRP) levels in patients with acute myocardial infarction. Methods Fifty-six AMI patients (AMI group) were enrolled in this study. Fifty-two healthy subjects (CON group) were enrolled in this study. Serum levels of MIP-1α and CRP were determined by blood sampling. The differences between the two groups were compared. Results Serum levels of MIP-1α in AMI patients were significantly higher than those in CON patients (P <0.001). CRP levels in patients with AMI were also significantly higher than those in CON patients (P <0.001). Conclusion MIP-1α and CRP play an important role in the occurrence and development of acute myocardial infarction.