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目的:研究盐酸氨溴索对慢性阻塞性肺疾病(COPD)急性加重期IL-8、TNF-α的影响。方法:选择2008年6月～2009年4月在新疆医科大学第五附属医院呼吸内科住院的慢性阻塞性肺疾病患者60例,入院时均为急性加重期,肺功能中度(Ⅱ级)、重度(Ⅲ级)。分为A组:常规治疗组;B组:常规治疗组+干预组,每组各30例。另外选择30例健康人为C组(健康对照组)。3组分别以性别、年龄、吸烟指数按1:1配对入组。A组给予控制性氧疗、抗感染等常规治疗,疗程7～10 d,病情达COPD稳定期标准。B组除给予控制性氧疗、抗感染等常规治疗外,加用盐酸氨溴索注射液60 mg,每日2次,静脉点滴,疗程7～10 d,病情达COPD稳定期标准。分别观察各组治疗前后血清IL-8、TNF-α水平。结果:(1)A组、B组治疗后血清IL-8、TNF-α水平均低于治疗前,差异具有统计学意义(P均<0.05);(2)A组、B组治疗前后血清IL-8、TNF-α水平均高于健康对照组,差异具有统计学意义(P均<0.05);(3)B组治疗后血清IL-8、TNF-α水平低于A组,差异具有统计学意义(P<0.05)。结论:盐酸氨溴索町以抑制COPD患者血清IL-8、TNF-a的释放,可能有一定的肺保护和治疗作用。
Objective: To study the effect of ambroxol hydrochloride on IL-8 and TNF-α in acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods: Sixty patients with chronic obstructive pulmonary disease hospitalized in Department of Respiratory Medicine, the Fifth Affiliated Hospital of Xinjiang Medical University from June 2008 to April 2009 were selected. All of them were exacerbated, moderate pulmonary function (grade Ⅱ) Severe (Ⅲ grade). Divided into A group: conventional treatment group; B group: conventional treatment group + intervention group, 30 cases in each group. In addition, 30 healthy people were selected as group C (healthy control group). Three groups were sexed, age, smoking index by 1: 1 matching into the group. Group A received controlled oxygen therapy, anti-infection and other routine treatment, the course of 7 to 10 days, the disease reached the standard of stable COPD. In addition to routine oxygen therapy, anti-infection and other conventional treatment, B group was treated with ambroxol 60 mg twice daily for 7-10 days, and the disease reached the standard of stable COPD. The levels of serum IL-8 and TNF-α in each group were observed before and after treatment. Results: (1) The levels of serum IL-8 and TNF-α in group A and group B after treatment were lower than those before treatment (P <0.05). (2) (P <0.05). (3) The levels of serum IL-8 and TNF-α in group B after treatment were lower than those in group A, the differences were statistically significant Statistical significance (P <0.05). Conclusion: Ambroxol hydrochloride can inhibit the release of serum IL-8 and TNF-α in patients with COPD, which may have protective and therapeutic effects on lung.