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目的观察分析枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停的临床效果。方法选取2014年6月—2015年6月经诊断为原发性呼吸暂停患儿80例为研究对象,按随机数字表法分为对照组40例和观察组40例,对照组给予常规护理配合氨茶碱注射液治疗;观察组给予常规护理配合枸橼酸咖啡因治疗。观察患儿的PCO2、Pa O2检测值,患儿呼吸暂停的发作次数、发作时间、症状消除时间,并对治疗效果和不良反应进行观察分析。结果治疗后两组PCO2、Pa O2检测值均有所变,与治疗前比较差异有统计学意义(P<0.05);治疗后组间比较,观察组变化更显著(P<0.05);观察组患儿呼吸暂停次数、发作持续时间、症状消失时间均小于对照组,两组对比差异有统计学意义(P<0.05);观察组患儿治疗总有效率为75%,对照组为50%,差异有统计学意义(P<0.05);观察组不良反应为5%,对照组不良反应为20%,差异有统计学意义(P<0.05)。结论枸橼酸咖啡因在治疗患儿呼吸暂停方面效果优于氨茶碱,且不良反应小,临床值得推广。
Objective To observe and analyze the clinical effect of apocynum citrate and aminophylline in the treatment of apnea in premature infants. Methods Totally 80 children diagnosed as primary apnea from June 2014 to June 2015 were divided into control group (n = 40) and observation group (n = 40) by random number table method. The control group was given conventional nursing with ammonia Theophylline injection treatment; observation group given conventional nursing with citrate caffeine treatment. The PCO2 and PaO2 values, the number of episodes of apnea, the time of onset of symptoms and the elimination of symptoms in children were observed. The therapeutic effects and adverse reactions were observed and analyzed. Results After treatment, the values of PCO2 and PaO2 in both groups changed, with statistical significance (P <0.05), compared with those before treatment (P <0.05). After treatment, the changes in observation group were more significant (P <0.05) The number of apnea, the duration of attack and the disappearance of symptoms in both groups were less than those in the control group, with significant difference between the two groups (P <0.05). The total effective rate was 75% in the observation group and 50% in the control group, The difference was statistically significant (P <0.05). The adverse reaction was 5% in the observation group and 20% in the control group. The difference was statistically significant (P <0.05). Conclusion citrate caffeine in the treatment of children with apnea is better than aminophylline, and adverse reactions, clinical worth promoting.