目的探讨己烯雌酚治疗鼻中隔穿孔的疗效。方法在穿孔缘周双侧作1～2 mm创面,有利于清除坏死或瘢痕组织。将经己烯雌酚注射液浸润的薄棉片,置于穿孔黏膜表面湿敷,每天更换,连续7～14 d,观察局部黏膜增生情况。结果 30例患者均于湿敷后的20 d内穿孔闭合。穿孔直径<0.5 cm者平均7 d闭合,0.5～0.8 cm者平均11 d闭合,0.5～0.8 cm者平均13 d闭合。结论己烯雌酚局部湿敷治疗鼻中隔穿孔安全有效。 Objective To investigate the efficacy of diethylstilbestrol in the treatment of nasal septal perforation. Methods Bilateral perforation margin 1 ~ 2 mm wound, is conducive to the removal of necrotic or scar tissue. The diethylstilbestrol impregnated thin cotton sheet placed on the perforation mucosal surface wet compress, replaced daily for 7 to 14 days, observe the local mucosal hyperplasia. Results All 30 patients were perforation closed within 20 days after wetting. Perforation diameter <0.5 cm were closed for an average of 7 days, 0.5 ~ 0.8 cm averaged 11 days closed, 0.5 ~ 0.8 cm average 13 days closed. Conclusion DES is safe and effective in the treatment of nasal septum perforation.