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目的探讨宫瘤消胶囊对米非司酮治疗子宫肌瘤疗效的影响。方法选取2012年1月至2015年12月间连云港市东方医院收治的80例子宫肌瘤患者,采用随机数表法分为观察组与对照组,每组40例。观察组患者给予宫瘤消胶囊联合米非司酮治疗,对照组患者给予米非司酮治疗,对比两组患者的总有效率,治疗前后子宫体积、瘤体体积、性激素水平变化及不良反应等。结果观察组疾病控制率为92.5%,对照组疾病控制率为77.5%,观察组明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组与对照组患者的性激素水平与治疗前比较均显著改善,观察组孕酮、雌二醇、黄体生成素和卵泡刺激素水平低于对照组,差异有统计学意义(P<0.05)。结论宫瘤消胶囊能显著提高米非司酮治疗子宫肌瘤的临床疗效,改善临床症状,且安全性高,值得临床推广应用。
Objective To investigate the effect of Gongyuxiao capsule on the efficacy of mifepristone treatment of uterine fibroids. Methods Eighty patients with uterine fibroids who were treated in Dongfang Hospital of Lianyungang from January 2012 to December 2015 were randomly divided into observation group and control group with 40 cases in each group. The patients in observation group were treated with Mianyuoxiao capsule combined with mifepristone, the patients in control group were treated with mifepristone, the total effective rate was compared between the two groups, the uterus volume before and after treatment, tumor volume, sex hormone level changes and adverse reactions . Results The disease control rate was 92.5% in the observation group and 77.5% in the control group, which was significantly higher in the observation group than in the control group (P <0.05). After treatment, the levels of sex hormones in the observation group and the control group Compared with those before treatment, the levels of progesterone, estradiol, luteinizing hormone and follicle stimulating hormone in the observation group were significantly lower than those in the control group (P <0.05). Conclusion Miyaoma capsule can significantly improve the clinical efficacy of mifepristone in the treatment of uterine fibroids, improve clinical symptoms, and high safety, it is worthy of clinical promotion and application.