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目的评价高危型HPV基因型检测(Cobas HPV)在新疆宫颈癌筛查中的应用价值。方法对2014年09月~2015年8月在新疆自治区人民医院住院及门诊就诊行HC2、TCT检测、并有病理诊断结果的564位女性的宫颈细胞标本进行高危型HPV基因型检测。结果 HC2阳性率为83.86%,Cobas HPV阳性率为64.19%,TCT阳性率为61.52%;HC2诊断的灵敏度为94.4%(118/125),特异度为19.1%(84/439);Cobas HPV诊断的灵敏度为88.0%(110/125),特异度为42.6%(187/439),TCT诊断的灵敏度为54.4%(68/125),特异度为36.4%(160/439)。不同液基细胞学分级HR-HPV感染率不同,差异具有统计学意义(P<0.05),Cobas HPV与HC2总符合率为78.50%(Kappa=0.469)。结论 Cobas HPV在诊断CIN2+病变时优于HC2、TCT检测,Cobas HPV检测对ASCUS诊断分流优于HC2,Cobas HPV检测在新疆宫颈癌筛查中具有较高的临床应用价值。
Objective To evaluate the value of detecting high-risk HPV genotypes (Cobas HPV) in screening cervical cancer in Xinjiang. Methods High-risk HPV genotypes were detected in 564 women with cervical cytology from hospitalized and outpatient clinics in People’s Hospital of Xinjiang Uygur Autonomous Region from September 2014 to August 2015 in HC2 and TCT and pathological diagnosis. Results The positive rate of HC2 was 83.86%, the positive rate of Cobas HPV was 64.19%, the positive rate of TCT was 61.52%. The sensitivity of HC2 was 94.4% (118/125) and the specificity was 19.1% (84/439) The sensitivity and specificity were 88.0% (110/125) and 42.6% (187/439) respectively. The sensitivity of TCT was 54.4% (68/125) and the specificity was 36.4% (160/439). The different liquid-based cytology grade HR-HPV infection rates were different, the difference was statistically significant (P <0.05), Cobas HPV and HC2 total coincidence rate was 78.50% (Kappa = 0.469). Conclusions Cobas HPV is superior to HC2 and TCT in diagnosis of CIN2 + lesions. Cobas HPV test is superior to HC2 in diagnosing ASCUS, and Cobas HPV test has high clinical value in screening cervical cancer in Xinjiang.