目的:探讨符合计划生育政策、45周岁以上女性受卵助孕的可行性。方法:45~50周岁女性10例,其中4例已绝经,6例月经不规则。所有卵子均经卵细胞浆内单精子注射(ICSI)受精,冷冻所有胚胎,择期在激素替代(HRT)周期下行冷冻胚胎移植(FET)。结果:10个周期获得赠卵47个(平均4.7个),冷冻胚胎36个,解冻后获得可移植胚胎25个。在HRT的16~20天行FET。获生化妊娠7例(70%),移植4周后阴超见临床妊娠6例(60%)。5例为单胎,1例为双胎,其中1例孕2个月流产,其余5例均经剖宫产分娩健康新生儿,移植周期临床妊娠率60%,移植周期分娩率50%。最高分娩年龄51岁,为双胎。结论:体外受精-胚胎移植(IVF-ET)技术可成为治疗45岁以上卵巢功能衰退女性的助孕捷径;成熟的IVF-ET临床及实验室条件、子宫内膜受容性调整及黄体支持治疗是该项技术的三大关键因素;该技术可引发如卵子来源、高危妊娠并发症、高龄双亲等伦理及法律问题。 Objective: To investigate the feasibility of conception-assisted pregnancy of women over the age of 45 in line with the family planning policy. Methods: 10 women 45 to 50 years old, of whom 4 had been menopausal and 6 had irregular menstruation. All eggs were fertilized by intracytoplasmic sperm injection (ICSI), all embryos were frozen, and embryo transfer (FET) was frozen down the hormone replacement (HRT) cycle. Results: There were 47 donated eggs (average 4.7) in 10 cycles, 36 frozen embryos and 25 embryos which could be transplanted after thawing. HRT in the 16 to 20 days line FET. Seven biopsies (70%) were obtained, and six (60%) clinical pregnancies were found to be overcast after 4 weeks of transplantation. Five were singletons and one was twins. One of them was aborted in 2 months and the other 5 were delivered healthy cesarean. The clinical pregnancy rate was 60% and the delivery rate was 50%. The maximum age of birth is 51 years old, twins. CONCLUSIONS IVF-ET can be a convenient way to treat pregnancy in women over the age of 45 with ovarian failure. The clinical and laboratory conditions of mature IVF-ET, endometrial receptivity and luteal support are Three key elements of the technology; the technology can lead to ethical and legal issues such as the origin of eggs, complications at high risk of pregnancy, and elderly parents.