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一、成人呼吸窘迫症(ARDS) 实验研究较多,研究深度和广度较前明显提高,特别是在ARDS发病机制上取得了进展。自1982年以来成功地建立了犬油酸型,免、犬骨髓型及犬脂肪型RDS动物实验模型。对ARDS始发因素和发病机理也进行了系统研究,认为C_(5a)激活、C_(3a)参与扩大效应导致的多核粒细胞在肺内聚集可能是ARDS的始发因素。第四军医大学第一附属医院成功地建立了山羊肺淋巴瘘,对大肠杆菌内毒素所致急性肺损伤进行了研究,并指出,利用山羊淋巴瘘观察肺淋巴液的量和内含成份的改变为研究ARDS肺内液体和溶质交换提供了良好模型;氧自由基特别是脂质过氧化反应在内毒素肺损伤形成ARDS的过程中可能起了重要作用。第二军医大学第一附属医院采用
First, adult respiratory distress syndrome (ARDS) experimental study more, research depth and breadth significantly increased, especially in the pathogenesis of ARDS has made progress. Since 1982, successfully established animal models of dog oleic acid, free, canine bone marrow and dog fat RDS animal model. The origin and pathogenesis of ARDS were also systematically studied. It is suggested that the activation of C_ (5a) and the accumulation of multinucleated granulocytes in the lung due to the involvement of C_ (3a) may be the initiators of ARDS. First Affiliated Hospital of the Fourth Military Medical University successfully established goat pulmonary lymphatic fistula, endotoxin-induced acute lung injury in E. coli study and pointed out that the use of goat lymphatic fistula to observe the amount of lung lymph fluid and changes in the content of components It provides a good model for the study of pulmonary fluid and solute exchange in ARDS. Oxygen free radicals, especially lipid peroxidation, may play an important role in the formation of ARDS induced by endotoxin-induced lung injury. First Military Medical University Hospital Adopted