目的　探讨老年胰腺癌患者的临床表现和治疗及预后。方法　收集 1990～ 2 0 0 0年上海华山医院胰腺癌中心 180例经过手术治疗的老年胰腺癌患者 ,其中 4 6例行Whipple手术 ,包括 2 2例介入治疗后的区域性胰十二指肠切除术 ,观察术后并发症和 30d内的死亡率。 78例接受了姑息手术 ,5 4例仅做剖腹探查术。随访 6个月到 10年。结果　所有患者都成功地进行了手术。 4 8例经外科根治性切除者的死亡率为 6 .2 % ,并发症率为 2 0 .8% ,中位生存期为 2 6个月 ;78例姑息手术者平均存活 6个月 ,5 4例仅行剖腹探查术者平均生存期只有 3个月。结论　外科治愈性手术治疗有助于延长老年胰腺癌患者的生存期 ,改善患者的生存质量 Objective To investigate the clinical manifestations, treatment and prognosis of elderly patients with pancreatic cancer. METHODS: 180 elderly patients with pancreatic cancer who underwent surgery were recruited from 1990 to 2000 in Huashan Hospital of Shanghai. Among them, 46 patients underwent Whipple surgery, including 22 patients undergoing regional pancreatoduodenectomy after interventional therapy. Surgery, postoperative complications and mortality within 30 days were observed. 78 patients underwent palliative surgery and 54 patients underwent laparotomy. Follow-up from 6 months to 10 years. Results All patients were successfully operated. The mortality rate of 48 patients undergoing radical resection was 6.2%, the complication rate was 20.8%, and the median survival period was 26 months. 78 patients who had palliative surgery survived an average of 6 months. 5 The average survival time of 4 patients who underwent laparotomy was only 3 months. Conclusion Surgical curative surgery can help extend the survival of elderly patients with pancreatic cancer and improve their quality of life