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大鼠灌服冰片制剂后能明显提高庆大霉素在脑内的浓度,提示冰片有改善血脑屏障通透性的作用,此结果对庆大霉素治疗细菌性脑膜炎和其它颅内炎症具有重要的临床意义。在改善血脑屏障通透性,增加庆大霉素进入脑内药量的同时,冰片还能提高血清中庆大霉素浓度,这为减少庆大霉素用药剂量,保证药效,降低庆大霉素的毒副反应,提高临床治疗作用提供了有力的实验依据。
Rats administered ibuprofen can markedly increase the concentration of gentamycin in the brain, suggesting that borneol can improve the permeability of the blood-brain barrier. This result can be used to treat bacterial meningitis and other intracranial inflammation with gentamicin. Has important clinical significance. In improving the permeability of the blood-brain barrier and increasing the dose of gentamicin into the brain, borneol can also increase the concentration of gentamicin in the serum. This reduces the dose of gentamicin, ensures efficacy, and reduces The toxic side effects of the damycin provide a powerful experimental basis for improving the clinical therapeutic effect.