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用体外培养法观察药物对恶性疟原虫的抑制作用及约氏疟原虫感染小鼠4d抑制试验法,对24种药物进行了比较,结果表明大部分药物在两种方法中表现出相仿的效果,但有个别如羟基脲及洁霉素体外及小鼠试验的结果不尽相符。作者对宜用何种方法作为抗疟药物初筛试验问题作了讨论。
The inhibition of Plasmodium falciparum and Plasmodium yoelii infection in mice 4d inhibition test were observed by in vitro culture method. The comparison of 24 drugs showed that most of the drugs showed similar effects in the two methods, But there are some such as hydroxyurea and lincomycin in vitro and mouse test results do not match. The authors discuss what methods should be used as primary screening tests for antimalarial drugs.