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目的观察扶正祛邪颗粒对呼吸道病毒感染人群免疫细胞及细胞因子的影响。方法59例患者随机分为3组,即治疗组(19例,用常规西药加中药治疗)、西药组(19例,单用常规西药治疗)和中药组(21例,单用中药治疗),分别于治疗前、治疗1周和2周测定T淋巴细胞亚群、白细胞介素(IL2、4、6、10)、肿瘤坏死因子α(TNFα)、干扰素γ(IFNγ)及Th1/Th2比值的变化。结果3组患者治疗前TNFα、IL2、IL6、IL10和IFNγ水平均比健康人明显升高(P<0.05),治疗1周时血清TNFα、IL6、IL10水平比治疗前明显降低(P<0.05);西药组血清IL2和IFNγ于第2周时已降至正常,治疗组及中药组至第2周时血清IL2和IFNγ浓度仍保持较高水平(P<0.05)。血清IL4水平3组治疗前后比较差异无显著性。治疗第2周时治疗组和中药组Th1/Th2比值比西药组和治疗前升高(P<0.05);3组T淋巴细胞亚群(CD3+、CD4+、CD8+)和分类(B和NK)细胞百分比治疗前后比较差异无显著性。结论扶正祛邪颗粒在一定程度上能正面调节上呼吸道病毒感染人群的免疫功能。
Objective To observe the effect of Fuzheng Quxie Granule on immune cells and cytokines in respiratory tract infected population. Methods Fifty-nine patients were randomly divided into three groups: treatment group (nineteen cases treated with conventional Western medicine plus traditional Chinese medicine), western medicine group (nineteen cases treated with conventional western medicine only), and traditional Chinese medicine group (n = 21 cases treated with traditional Chinese medicine only). The T lymphocyte subsets, interleukin (IL2, 4, 6, 10), tumor necrosis factor α (TNFα), interferon γ (IFNγ) and Th1/Th2 ratios were determined before treatment, 1 week, and 2 weeks of treatment. The change. Results The levels of TNFα, IL2, IL6, IL10 and IFNγ in the three groups before treatment were significantly higher than those in healthy subjects (P<0.05). Serum levels of TNFα, IL6, and IL10 were significantly lower than those before treatment in the three groups (P<0.05). Western medicine group serum IL2 and IFN gamma have been reduced to normal at the second week, the serum IL2 and IFN gamma concentration of the treatment group and the Chinese medicine group to the second week still maintain a high level (P <0.05). There was no significant difference in serum IL4 levels between the 3 groups before and after treatment. At the 2nd week of treatment, the ratio of Th1/Th2 in the treatment group and the TCM group was higher than that in the western medicine group and before treatment (P<0.05); the T lymphocyte subsets (CD3+, CD4+, CD8+) and classification (B and NK) cells in the 3 groups There was no significant difference between the percentage before and after treatment. Conclusion Fuzheng Quxie Granules can positively regulate the immune function of upper respiratory tract virus infected people to a certain extent.