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目的探讨妊娠合并梅毒的临床特点、早期诊治对妊娠结局、围生儿预后的临床意义。方法18例血清学检查确诊为梅毒的孕妇,根据妊娠期梅毒发现时间及治疗情况,分为全程治疗组(8例)、非全程治疗组(6例)、未治疗组(4例),比较三组孕妇的妊娠结局、先天梅毒儿的发生情况,观察治疗时期、疗程与新生儿先天梅毒的发生关系。结果全程治疗组足月分娩率为100%(8/8),高于非全程治疗组的66.6%(4/6)和未治疗组的50%(2/2),三者相比差异有统计学意义(P<0.01);死胎2例均发生在未治疗组;未治疗组先天梅毒儿发生率为75%(3/4),高于非治疗组的33.4%(2/6)和全程治疗组的12.5%(1/8),三者相比差异有统计学意义(P<0.01)。结论早期诊断、早期规范治疗对于改善合并梅毒感染的孕产妇的妊娠结局率、降低围生儿死亡、减少先天梅毒儿发生具有重要意义。
Objective To investigate the clinical features of syphilis during pregnancy, early diagnosis and treatment of pregnancy outcome, the prognosis of perinatal clinical significance. Methods 18 pregnant women diagnosed as syphilis by serological test were divided into full treatment group (n = 8), non-full treatment group (n = 6) and untreated group (n = 4) according to the time and treatment of syphilis during pregnancy. Three groups of pregnant women’s pregnancy outcome, the incidence of congenital syphilis, observe the treatment period, treatment and neonatal congenital syphilis occurred. Results The full-term delivery rate was 100% (8/8) in the full treatment group, which was higher than 66.6% (4/6) in the non-full treatment group and 50% (2/2) in the untreated group The incidence of congenital syphilis in untreated group was 75% (3/4), which was higher than that in non-treated group (33.4%, 2/6) and The whole treatment group 12.5% (1/8), the difference between the three was statistically significant (P <0.01). Conclusion Early diagnosis and early standard treatment are of great significance for improving the pregnant rate of pregnant women with syphilis infection, reducing perinatal mortality and reducing the incidence of congenital syphilis.