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目的总结胃动蛋白基因1(gastrokine 1,GKN1)在胃黏膜相关疾病中的作用及机理,探讨GKN1与胃黏膜相关疾病的关系。方法复习近年来国内外关于GKN1与胃黏膜相关疾病的研究文献以进行综述。结果GKN1的表达水平从胃炎、胃溃疡到胃癌依次逐渐下调。GKN1具有保护胃黏膜、促进黏膜修复和抑制胃癌发生发展的作用。结论 GKN1不仅可以抑制胃良性疾病向胃癌的发展,而且可以抑制胃癌的进展,这为胃癌的诊治提供了新的思路。
Objective To summarize the role and mechanism of gastrokine 1 (GKN1) in gastric mucosa-associated diseases and to explore the relationship between GKN1 and gastric mucosa-associated diseases. Methods To review the literatures about GKN1 and gastric mucosa-related diseases at home and abroad in recent years for review. Results The expression level of GKN1 gradually decreased from gastritis and gastric ulcer to gastric cancer. GKN1 has the function of protecting the gastric mucosa, promoting mucosal repair and inhibiting the occurrence and development of gastric cancer. Conclusion GKN1 can not only inhibit the development of benign gastric diseases to gastric cancer, but also inhibit the progression of gastric cancer, which provides a new idea for the diagnosis and treatment of gastric cancer.