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目的探讨急性冠脉综合征患者IL-12和IL-18的血浆水平及其临床意义。方法采用ELISA方法测定急性冠脉综合征(ACS组)和稳定性心绞痛(SAP组)和对照组各70例患者血浆中IL-12和IL-18的水平,并进行比较。结果血浆IL-12水平,ACS组与SAP组均明显高于对照组,差异有统计学意义(P<0.01);血浆IL-18水平,ACS组与SAP组均明显高于对照组,差异有统计学意义(P<0.01);ACS组与SAP组组间比较,血浆IL-12和IL-18水平均有明显差异(P<0.05)。结论 IL-12和IL-18可能参与了冠状动脉粥样硬化病变的病理生理过程,炎性细胞因子水平的增高促进了动脉粥样硬化斑块的不稳定性,可能是促使ACS发生的机制之一。
Objective To investigate the plasma levels of IL-12 and IL-18 in patients with acute coronary syndrome and its clinical significance. Methods The levels of IL-12 and IL-18 in plasma of 70 patients with acute coronary syndrome (ACS group) and 70 patients with stable angina pectoris (SAP group) and the control group were determined by ELISA, and compared. Results The levels of plasma IL-12 in ACS group and SAP group were significantly higher than those in control group (P <0.01). The levels of plasma IL-18 in ACS group and SAP group were significantly higher than those in control group (P <0.01). There was significant difference between plasma levels of IL-12 and IL-18 in ACS group and SAP group (P <0.05). Conclusion IL-12 and IL-18 may be involved in the pathophysiological process of coronary atherosclerosis. Increased inflammatory cytokines promote the atherosclerotic plaque instability and may be the mechanism of ACS one.