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取绒毛进行染色体分析已成为早期妊娠产前诊断的一种可行的方法。但在临床普遍应用该技术之前,还需要进一步对其安全性和准确性做出评价。Daker等曾表示担心母体细胞污染、培养中自生的细胞遗传学外来物质以及真的染色体嵌合或非整倍体等问题可能随着绒毛组织在产前诊断中的应用而出现。最初关于绒毛组织的细胞遗传学研究报告中未直接评定母体细胞污染频率。最近有人报告绒毛培养中的母体细胞污染率为5.5%,这是以绒毛染色体核型分析鉴定为女性而最后证明为男胎的妊娠数为基础的。实际上这个比率应为11%,因当胎儿是女性时,尽管有母体细胞污染,被检查的是母体细
Fetching the chromosome for chromosome analysis has become a viable method of prenatal diagnosis of early pregnancy. But in the clinical application of the technology before the general, but also need to further evaluate its safety and accuracy. Daker et al. Have expressed concerns that maternal cell contamination, autologous cytogenetic foreign material in culture, and true chromosomal chimerism or aneuploidy may arise with the application of villous tissue in prenatal diagnosis. The initial report on cytogenetics in villous tissue did not directly assess the frequency of maternal cell contamination. Recently, it has been reported that the rate of maternal cell contamination in chorionic culture is 5.5%, which is based on the number of pregnancies identified as females by villus chromosome karyotyping and finally as male males. In fact this ratio should be 11%, because when the fetus is a woman, despite the maternal cell contamination, the mother is being examined fine