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成人隐匿性自身免疫性糖尿病(LADA)是指发病初期不需要胰岛素治疗的缓慢进展的自身免疫性糖尿病或1型糖尿病。UKPDS研究发现,初诊为2型糖尿病的成人患者中大约有10%存在胰岛自身免疫的证据,即循环中发现ICA和GAD-Ab阳性,其中大多数患者在6年内进展为胰岛素依赖状态。在临床实践
Adult latent autoimmune diabetes (LADA) refers to the slow progression of autoimmune diabetes or type 1 diabetes that does not require insulin therapy during the early stages of disease. UKPDS study found that about 10% of adult patients with newly diagnosed type 2 diabetes have evidence of islet autoimmunity, ICA and GAD-Ab positive in the circulation, most of whom progress to insulin-dependent status within 6 years. In clinical practice