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目的探讨头孢哌酮/舒巴坦联合奥硝唑治疗妇科感染的临床疗效,为临床抗菌治疗策略的制定提供参考。方法选取医院收治的各类妇科感染患者292例,随机分为观察组和对照组,各146例;对照组采用头孢哌酮/舒巴坦静脉滴注进行治疗,观察组在对照组治疗方案的基础上,加用奥硝唑静脉滴注进行治疗;在治疗前后均采集相应部位的分泌物检测病原菌,对比两组患者的病原菌清除率、临床疗效和不良反应发生率。结果妇科感染病原菌检出率最高为大肠埃希菌,其次为肺炎克雷伯菌;两组患者治疗前均检出病原菌113株,检出率均为77.40%;观察组治疗后的病原菌清除率为90.27%,显著高于对照组(P<0.05);经过治疗后,观察组的总治愈率为51.37%,总有效率为81.51%,对照组分别为36.99%和71.23%,观察组的总治愈率和总有效率均显著高于对照组(P<0.05);在治疗过程中,对照组的不良反应发生率为17.12%,观察组的不良反应发生率为15.07%,差异无统计学意义。结论头孢哌酮/舒巴坦联合奥硝唑治疗可提高妇科感染的临床疗效,更有效地清除病原菌,且安全性高,值得临床推广应用。
Objective To investigate the clinical efficacy of cefoperazone / sulbactam combined with ornidazole in the treatment of gynecological infections and provide reference for the development of clinical antimicrobial treatment strategies. Methods A total of 292 cases of gynecological infection were selected in the hospital and randomly divided into observation group and control group with 146 cases in each group. The control group was treated with cefoperazone / sulbactam intravenous drip, and the observation group in the control group On the basis, plus ornidazole intravenous infusion treatment; before and after treatment were collected the corresponding parts of the secretion detection of pathogens, compared to two groups of patients pathogenic bacteria clearance, clinical efficacy and adverse reactions. Results The highest detection rate of gynecological infection was Escherichia coli, followed by Klebsiella pneumoniae. 113 strains of pathogens were detected in both groups before treatment, the detection rates were 77.40%. The pathogen clearance (90.27%) was significantly higher than that of the control group (P <0.05). After treatment, the total cure rate was 51.37% in the observation group and the total effective rate was 81.51% in the control group and 36.99% and 71.23% in the control group, respectively Cure rate and total effective rate were significantly higher than the control group (P <0.05); in the course of treatment, the incidence of adverse reactions in the control group was 17.12%, the incidence of adverse reactions in the observation group was 15.07%, the difference was not statistically significant . Conclusion Cefoperazone / sulbactam combined with ornidazole can improve the clinical efficacy of gynecological infection, remove pathogens more effectively and have high safety, which is worthy of clinical application.