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目的 :探讨伴骨髓瘤的 POEMS综合征的临床特点。方法 :对国内 8例伴骨髓瘤的 POEMS综合征患者的临床资料进行综合分析。结果 :伴骨髓瘤的 POEMS综合征是一种临床上多系统受累疾病 ,严重的感觉运动性神经病变症状常为患者的主诉 ,其他主要表现有器官肿大、内分泌病、皮肤改变等。发病多为中青年男性 ,影像学检查除溶骨性骨破坏外 ,易伴成骨性骨改变。 6例经治疗 4例好转 ,1例无效 ,1例死亡。结论 :伴骨髓瘤的 POEMS综合征是骨髓瘤中的一种特殊类型
Objective: To investigate the clinical features of POEMS syndrome with myeloma. Methods: The clinical data of 8 patients with POEMS syndrome with myeloma were analyzed comprehensively. Results: The POEMS syndrome with myeloma is a clinically multisystem disease. The symptoms of severe sensorimotor neuropathy are often the main complaints of the patient. Other major manifestations include organ enlargement, endocrinopathy, and skin changes. Most of the patients were young and middle-aged males, and imaging examinations were accompanied by osteogenic bone changes in addition to osteolytic bone destruction. In 6 cases, 4 cases were improved, 1 case was invalid, and 1 case died. Conclusion: POEMS syndrome with myeloma is a special type of myeloma