Amino-functionalized SBA-15(SBA-Pr-NH2) has been used as a new basic nanocatalyst in the one-pot synthesis of spirooxindole derivatives via the three-component condensation reaction of isatins, activated methylene reagents, and dimedone in an aqueous medium. SBA-Pr-NH2 has been established as an efficient heterogeneous nanoporous solid basic catalyst (pore size of 6 nm) that can be easily handled and removed from the reaction mixture by simple filtration, and also recovered and reused without noticeable loss of reactivity.