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目的通过研究CXCL12和VEGF在造釉细胞型颅咽管瘤中的表达情况,探讨CXCL12和VEGF表达与造釉细胞型颅咽管瘤复发转移之间的关系。方法应用免疫组化检测50例造釉细胞型颅咽管瘤标本(原发组29例,复发组21例)中CXCL12和VEGF的表达情况。结果造釉细胞型颅咽管瘤中,CXCL12在复发组的总阳性表达率95.2%明显高于原发组的44.8%(Z=-3.456,P<0.05);VEGF在复发组的总阳性表达率90.5%明显高于原发组的62.1%(Z=-2.996,P<0.05)。复发组釉质细胞型颅咽管瘤中CXCL12与VEGF之间的表达存在相关性(r=0.581,P<0.05)。但是在原发组中CXCL12与VEGF表达并没有相关性(r=-0.029,P>0.05)。结论在造釉细胞型颅咽管瘤中CXCL12和VEGF的高表达能协同促进肿瘤的复发转移。CXCL12和VEGF可以作为造釉细胞型颅咽管瘤重要的生物学行为预测和预后指标。
Objective To investigate the expression of CXCL12 and VEGF in glaucoma craniopharyngioma and to investigate the relationship between the expression of CXCL12 and VEGF and the recurrence and metastasis of glaucoma craniopharyngioma. Methods The expression of CXCL12 and VEGF in 50 cases of glaucoma craniopharyngioma specimens (29 cases in primary group and 21 cases in recurrence group) were detected by immunohistochemistry. Results In glaucoma craniopharyngioma, the total positive expression rate of CXCL12 in the recurrence group was significantly higher than that in the primary group (95.2% vs 44.8%, Z = -3.456, P <0.05) The rate of 90.5% was significantly higher than that of the primary group (62.1%, Z = -2.996, P <0.05). There was a correlation between the expression of CXCL12 and VEGF in recurrent group of enamel cell craniopharyngioma (r = 0.581, P <0.05). However, there was no correlation between the expression of CXCL12 and VEGF in primary group (r = -0.029, P> 0.05). Conclusion The high expression of CXCL12 and VEGF in glaucoma craniopharyngioma can synergistically promote tumor recurrence and metastasis. CXCL12 and VEGF can be used as predictors and predictors of biological behavior in glaucoma craniopharyngioma.