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目的探讨白细胞介素32蛋白在胃癌及其癌旁组织中的表达情况,并分析与临床病理特征之间的相关性。方法采用免疫组织化学法检测胃癌和癌旁组织中白细胞介素32蛋白的表达情况,并结合临床病理资料进行分析。结果胃癌组织中白细胞介素32蛋白的阳性表达率为95%(19/20),明显高于癌旁组织的表达率14.3%(1/7),差异有统计学意义(P<0.05)。白细胞介素32蛋白阳性表达与肿瘤细胞的浸润深度、TNM分期、性别、年龄及有无淋巴结转移无相关性(P>O.05)。结论白细胞介素32在胃癌组织中呈过表达,白细胞介素32蛋白的表达与年龄、性别、肿瘤浸润、肿瘤分期及淋巴转移无关。
Objective To investigate the expression of interleukin-32 (IL-32) in gastric cancer and its paracancerous tissues and to analyze the correlation with the clinicopathological features. Methods Immunohistochemistry was used to detect the expression of interleukin 32 protein in gastric cancer and paracancerous tissues. The clinical data were analyzed. Results The positive rate of interleukin 32 protein in gastric cancer tissues was 95% (19/20), which was significantly higher than that in paracancerous tissues (14.3%, 1/7) (P <0.05). The positive expression of IL - 32 protein had no correlation with tumor cell infiltration depth, TNM stage, sex, age and lymph node metastasis (P> 0.05). Conclusion Interleukin-32 is overexpressed in gastric cancer tissue. The expression of interleukin-32 protein is not related to age, gender, tumor invasion, tumor stage and lymphatic metastasis.