论文部分内容阅读
目的:以往研究都表明,2型糖尿病患者易发生体位性低血压,但该人群的体位性高血压的临床重要性及患病率情况如何并不清楚。方法:选择连续入院277例2型糖尿病患者,包括90例高血压患者及128例年龄匹配的非糖尿病个体。体位性高血压定义为体位便从卧位变为立位时,收缩压和(或)舒张压从140mmHg/90mmHg以下上升并超过140/90mmHg。所有受试者均采集临床资料及生化指标。结果:体位性高血压的在糖尿病患者中患病率都显著高于对照组(12.8 vs 1.8%,P<0.01)。糖尿病合并体位性高血压患者由体位变化引起的血压水平增加程度显著高于糖尿病不合并体位性高血压的患者。(收缩压平均变化值:6.8±11.4 vs 1.6±9.0 mmHg,P<0.05;舒张压平均变化值:9.1±5.2 vs 3.8±6.6 mmHg,P<0.005)。糖尿病合并体位性高血压的患者血压水平及血清甘油三酯水平均高于其他组(P<0.05)。结论:2型糖尿病患者合并早期神经病变更易出现体位性高血压,并且可能是糖尿病患者发展为原发性高血压的危险因素。
PURPOSE: Previous studies have shown that orthostatic hypotension tends to occur in patients with type 2 diabetes, but its clinical significance and prevalence are not clear. METHODS: A total of 277 patients with type 2 diabetes mellitus, including 90 hypertensive patients and 128 age-matched non-diabetic individuals, were enrolled in this study. Orthostatic hypotension is defined as a rise in systolic and / or diastolic blood pressure from 140 mmHg / 90 mmHg to greater than 140/90 mmHg as the position changes from lying position to standing position. All subjects were collected clinical data and biochemical indicators. Results: The prevalence of orthostatic hypertension in diabetic patients was significantly higher than that in the control group (12.8 vs 1.8%, P <0.01). Diabetic patients with orthostatic hypertension caused by changes in posture was significantly higher than the level of blood pressure increased in patients with diabetes mellitus without hypertension. (Mean systolic BP: 6.8 ± 11.4 vs. 1.6 ± 9.0 mmHg, P <0.05; mean diastolic BP: 9.1 ± 5.2 vs 3.8 ± 6.6 mmHg, P <0.005). Blood pressure and serum triglyceride levels were significantly higher in diabetic patients with orthostatic hypertension than those in other groups (P <0.05). Conclusions: Type 2 diabetes mellitus is more prone to orthostatic hypertension with early neuropathy, and may be a risk factor for the development of hypertension in patients with type 2 diabetes mellitus.