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为探讨系统性红斑狼疮（systemiclupuserythematosus，SLE）患者血清抗心磷脂抗体的阳性率及其与患者病情活动性关系，用酶联免疫吸附法的ACAIg含量测定药盒（ELISA）对87例SLE患者血清ACAIg含量进行了测定。结果：全组患者的ACAIgG、ACAIgA和ACAIgM阳性率分别为62．1％、52．9％和35.6％。ACAIgG、ACAIgM测定值与代表SLE活动性的病情积分呈正相关（r＝0．2763，P＝0．044；r＝0．3294，P＝0．018）。ACAIgG、ACAIgA、ACAIgM与补体C3呈负相关（r＝－0．4737，P＝0．000；r＝－0．2990，P＝0．017；r＝－0.2758，P＝0．029）；ACAIgG与补体C4呈负相关（r＝－0．4079，P＝0．005）。并发血栓时，ACAIgA增高。并发狼疮脑病时，ACAIgG、ACAIgM测定值的变化校无此并发症者明显增高。由此表明ACA测定值的变化可以客观反映SLE患者的病情活动性。并发血栓时，ACAIgA增高。并发狼疮脑病时，ACAIgG、ACAIgM测定值增高。
In order to explore the positive rate of serum anticardiolipin antibodies in patients with systemic lupus erythematosus (SLE) and its relationship with the patient’s disease activity, enzyme linked immunosorbent assay (ELISA) ACAIg content was measured. Results: The positive rates of ACAIgG, ACAIgA and ACAIgM in the whole group were 62.1%, 52.9% and 35.6% respectively. The ACAIgG and ACAIgM values were positively correlated with the disease scores representing the activity of SLE (r = 0.2763, P = 0.044; r = 0.3294, P = 0.018). ACAIgG, ACAIgA and ACAIgM were negatively correlated with complement C3 (r = -0.4737, P = 0.000; r = -0.2990, P = 0.017; r = -0.2758, P = 0.029) ACAIgG was negatively correlated with complement C4 (r = -0.4079, P = 0.005). Accompanied by thrombosis, ACAIgA increased. Concurrent with lupus encephalopathy, ACAIgG, ACAIgM measured changes in school without such complications were significantly higher. This shows that changes in ACA measured values can objectively reflect the SLE patients with disease activity. Accompanied by thrombosis, ACAIgA increased. Accompanied by lupus encephalopathy, ACAIgG, ACAIgM measured values increased.