Photodynamic therapy (PDT) is a widely-used technology for cancer therapy,but conventional photosensitizers still face some drawbacks,such as hydrophobicity,inadequate pharmacokinetics,low cell/tissue specificity,and uncontrollable photodynamic performance during the therapeutic process.Herein,we present a controllable photodynamic performance based on two-dimensioral metal-organic frameworks (2D Zn-TCPP MOF) that displayed a week PDT effect under a neutral environment upon exposure to a 660 nm laser due to the degeneracy of Q bands of TCPP.However,the 2D Zn-TCPP MOF siowed a significantly enhanced PDT effect in an acidic environment under irradiation with a 660 nm laser due to the released TCPP from decomposed MOF structure.From thein vitro outconee,the 2D Zn-TCPP MOF showed controllable photocdynamic perfomnance from neutral to acidic environments.Due to the acldic tumor microenvironment,the 2D Zn-TCPP MOF presented the strongest antitumor effect in vivo under Irradiation with a 660 nm laser.This work offers a promising strategy to develop a next-generation photosensitizer.