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目的观察劳力型围术期心绞痛患者使用氨氯地平的治疗效果,分析患者对药物的耐受性。方法选取医院收治的劳力型围术期心绞痛患者90例作为研究对象,随机分为观察组和对照组,每组45例。2组均接受常规抗心绞痛治疗,在此基础上观察组应用氨氯地平治疗,持续用药6个月,观察2组心绞痛发作次数、硝酸甘油用量、运动试验结果,统计用药期间不良反应发生情况。结果治疗后,2组心绞痛发作频率、硝酸甘油消耗量较治疗前均改善,且观察组改善程度优于对照组(P<0.05);2组运动持续时间、总工作量较治疗前均改善,且观察组改善程度优于对照组(P<0.05)。治疗后,观察组收缩压降低,与对照组比较差异有统计学意义(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。2组治疗前后肝、肾功能,血尿常规无明显变化。结论劳力型围术期心绞痛患者应用氨氯地平结合常规方案治疗,疗效显著,且无不良反应。
Objective To observe the therapeutic effect of amlodipine in patients with labor-perioperative angina pectoris and to analyze the patient’s tolerance to drugs. Methods Totally 90 cases of labor perioperative angina pectoris admitted to hospital were selected as research object and randomly divided into observation group and control group with 45 cases in each group. Both groups received conventional anti-angina treatment. On the basis of this, the observation group was treated with amlodipine for 6 months. The number of angina attacks, the dosage of nitroglycerin, the results of exercise test and the adverse reactions during the treatment were observed. Results After treatment, the frequency of angina pectoris and the consumption of nitroglycerin in both groups were improved compared with that before treatment, and the improvement in observation group was better than that in control group (P <0.05). The duration of exercise and total workload in two groups were improved, And the observation group improved better than the control group (P <0.05). After treatment, the observation group systolic blood pressure decreased compared with the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Before and after treatment, the liver and kidney function and hematuria did not change obviously in the two groups. Conclusion Labor-peri-operative patients with angina pectoris should be treated with amlodipine in combination with conventional regimen, with significant curative effect and no adverse reactions.