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目的探讨结直肠癌伴低钠血症患者血清学特点及预后因素。方法回顾2012年2月—2014年4月诊治的113例结直肠癌患者血清学指标及随访3年生存资料并进行分析,采用SPSS18.0软件对数据进行统计分析,计数资料采用χ2检验,单因素及多因素生存分析采取Logistic回归分析,P<0.05差异有统计学意义。结果低钠血症组白细胞计数、血肌酐、癌胚抗原水平均值及95%可信区间均高于血钠正常组,在血红蛋白及白蛋白水平上,低钠血症组均值及95%可信区间均低于血钠水平正常组(均P<0.05)。;多因素Logistic回归分析显示:肿瘤TNM分期、肿瘤细胞分化程度、癌胚抗原水平、血钠水平是结直肠癌患者3年生存结局独立影响因子(均P<0.05)。结论血钠水平是影响结直肠癌患者3年生存结局独立影响因子,血钠水平降低提示预后不良,对于临床诊疗及判断预后具有重要作用。
Objective To investigate the serological features and prognostic factors of patients with colorectal cancer with hyponatremia. Methods The clinical data of 113 patients with colorectal cancer diagnosed and treated from February 2012 to April 2014 were retrospectively analyzed and analyzed. SPSS18.0 software was used to analyze the data. The count data were analyzed by χ2 test. Factors and multivariate survival analysis using Logistic regression analysis, P <0.05 was considered statistically significant. Results The mean white blood cell count, serum creatinine, carcinoembryonic antigen level and 95% confidence interval in hyponatremia group were all higher than those in normal sodium group. At the level of hemoglobin and albumin, the mean and 95% confidence level of hyponatremia group Intervals were lower than the normal level of serum sodium (P <0.05). Multivariate Logistic regression analysis showed that TNM staging, tumor cell differentiation, carcinoembryonic antigen level and serum sodium level were independent influencing factors of 3-year survival in patients with colorectal cancer (all P <0.05). Conclusions Serum sodium level is an independent influencing factor of 3-year survival outcome in patients with colorectal cancer. Decreased serum sodium level indicates a poor prognosis, which plays an important role in clinical diagnosis and prognosis.