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目的了解2型糖尿病(T2DM)患者合并不同并发症时的肾功能特征及糖尿病肾病(DN)患病的危险因素,为DN的预防控制提供参考依据。方法收集3 149份T2DM患者的病历资料,根据并发症情况分为单纯T2DM组、T2DM微血管病变组、T2DM大血管病变组和T2DM同时合并微血管病变和大血管病变组;分析4组患者肾功能(尿肌酐、双肾小球滤过率、血尿酸、血肌酐)的特征及差异,并采用多因素非条件Logistic回归模型分析DN的主要危险因素。结果单纯T2DM组、T2DM微血管病变组、T2DM大血管病变组、T2DM同时合并微血管病变和大血管病变组血肌酐、血尿酸含量差异有统计学意义(P<0.05);3 149例T2DM患者中DN患病率为(17.1%);多因素Logistic回归分析结果表明,年龄、病程及肥胖是T2DM患者DN患病的危险因素。结论T2DM患者同时出现微血管和大血管病变时肾脏的代谢功能可严重受损;年龄、病程及肥胖是DN患病的主要危险因素。
Objective To investigate the renal function and risk factors of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM) complicated with various complications and provide a reference for the prevention and control of DN. Methods The data of medical records of 3 149 T2DM patients were collected. According to the complication, the patients were divided into two groups: T2DM group, T2DM group, T2DM group and T2DM group. The changes of renal function Urine creatinine, glomerular filtration rate, serum uric acid, serum creatinine) were analyzed. The main risk factors of DN were analyzed by multivariate non-conditional logistic regression model. Results The levels of serum creatinine and serum uric acid in T2DM group, T2DM group, T2DM group and T2DM group were significantly higher than those in T2DM group (P <0.05). The DN of 3 149 T2DM patients with DN The prevalence was (17.1%). Multivariate logistic regression analysis showed that age, course of disease and obesity were the risk factors of DN in T2DM patients. Conclusions The metabolic function of renal in T2DM patients with microvascular and macrovascular complications may be seriously impaired. Age, course of disease and obesity are the major risk factors of DN.