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实验采用刚断奶的雄性大白鼠,给予含1%乳清酸及适量受试物的基础食物喂养14天。每天测定食物的消耗量,最后计算平均值。用断头术处死大白鼠,血清作凝胶电泳并分析了肝脏的甘油三脂、胆固醇以及α-磷酸甘油脱氢酶的活性,获得各种降血脂药物预防脂肪肝的测定曲线。利用这些测定曲线,即能比较各种降血脂药物预防实验性脂肪肝的效力。本试验中所列药物的效力几乎
The experiment weaned the male rats, given 1% orotic acid and appropriate amount of test substance-based food for 14 days. The daily consumption of food determination, and finally calculate the average. The rats were sacrificed by decapitation, the serum was analyzed by gel electrophoresis and the activities of triglyceride, cholesterol and α-phosphoglycerate dehydrogenase in the liver were analyzed, and the determination curves of various antihyperlipidemic drugs in preventing fatty liver were obtained. Using these assay curves, one can compare the efficacy of various lipid-lowering drugs in preventing experimental fatty liver disease. The efficacy of the drugs listed in this test is almost