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目的 对国内四个生产厂家的法莫替丁片及胶囊进行了体外溶出度对比实验 ,观察其体外溶出度。方法 采用 1995年版药典二部转蓝法 ,以人工胃液为介质 ,用紫外分光光度法测定含量。结果 各产品溶出度均符合规定 ,但溶出常数经 t法检查 ,D样品 T5 0 与其它产品差异显著 (P<0 .0 5 )。结论 剂型影响溶出度。
OBJECTIVE To compare the in vitro dissolution of famotidine tablets and capsules from four domestic manufacturers and observe its in vitro dissolution rate. Methods The Pharmacopoeia of the second edition of 1995 was used to change the blue method. The content of artificial gastric juice was determined by UV spectrophotometry. Results The dissolution rate of each product met the requirements, but the dissolution rate was examined by t test. The difference of T5 0 between D sample and other products was significant (P <0.05). Conclusion The dosage form affects the dissolution rate.