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针对方剂配伍中药物的相互作用现象,提出了方剂的“耦合”效应概念。药物配伍对方剂的耦合效应可产生3种不同的结果或现象,即协同效应、叠加效应和拮抗效应。并具体分析了方剂配伍理论“君臣佐使”和“七情和合”理论中的耦合效应类型,对方剂配伍作用进行数学上的阐释。方药之间的配伍所产生的“耦合”效用并不是固定不变的,它随剂量、所治病证、剂量配比的变化而变化。
Aiming at the phenomenon of drug interaction in prescription compatibility, the concept of “coupling” effect of prescription is proposed. The effect of the drug on the coupling effect of the agent can produce three different results or phenomena, namely synergistic effect, superposition effect and antagonistic effect. And concretely analyzed the coupling effect type in the theory of compatibility of prescriptions, the theory of the relationship between the monarch and the minister and the theory of the seven emotions, and explained mathematically the role of compatibility of the prescription. The compatibility of prescription drugs produced “coupling ” utility is not fixed, it varies with dose, the treatment of disease, dose ratio changes.