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目的观察抗焦虑抑郁药物联合质子泵抑制剂(PPI)和胃肠动力药治疗功能消化不良(fuctional dyspepsoa,FD)的疗效。方法选择120例经PPI治疗无效的上腹痛综合征(epigastric pain syndriome,EPS)患者和130例经枸橼酸莫沙必利分散片治疗无效的餐后不适综合征(postpran dialdistress syndrome,PDS)患者,随机分为治疗组和对照组。治疗1组(EPS)在口服奥美拉唑20mg,每天1次的基础上加用抗焦虑抑郁药中药舒肝解郁胶囊2粒,每日2次,治疗4周;对照1组仅给予奥美拉唑胶囊20mg,每天1次。治疗2组(PDS)在口服莫沙必利分散片5mg,每天3次的基础上加用抗焦虑抑郁药中药舒肝解郁胶囊2粒,每日2次,治疗4周;对照2组给予莫沙必利分散片5mg,每天3次。结果两治疗组有效率均高于各自对照组(P<0.05)。结论功能性消化不良与精神心理因素有关,联合抗焦虑抑郁药物治疗可提高临床疗效。
Objective To observe the efficacy of anti-anxiety and depression drugs combined with proton pump inhibitor (PPI) and gastrointestinal motility drug in the treatment of dysfunctional dyspepsia (FD). Methods One hundred and twenty patients with epigastric pain syndrome (epigastric pain syndriome, EPS) who were ineffective with PPI and 130 patients with postprandial dialdistress syndrome (PDS) who were inactive with mosapride citrate dispersible tablets , Were randomly divided into treatment group and control group. Treatment group 1 (EPS) oral omeprazole 20mg, 1 times a day based on the use of anti-anxiety depression drug Shugan Jieyu capsule 2 capsules twice daily for 4 weeks; control group 1 only to the Austrian Melazolol capsules 20mg, 1 times a day. Treatment group 2 (PDS) in the oral mosapride dispersible tablets 5mg, 3 times a day plus anti-anxiety depression drug Shugan Jieyu capsule 2 capsules twice daily for 4 weeks; control group 2 Mosapride dispersible tablets 5mg, 3 times a day. Results The effective rates of the two treatment groups were higher than those of the control group (P <0.05). Conclusions Functional dyspepsia is related to mental and psychological factors. Combined with anti-anxiety and depression drug therapy can improve clinical efficacy.