用低铜奶方喂养的早产儿及由于严重的腹泻、吸收障碍、蛋白质丢失,或使用螯合剂的婴儿用完全胃肠外营养而没有增补铜所引起的铜缺乏症均有报告。铜缺乏症可以引起贫血及其他难以捉摸的症状,用丰富的饮食可以消除,故不易诊断。例1 因呕吐及呆滞而入院的一名6个月的阿拉伯男婴,初生体重3500g,生后仅用牛奶喂养,查体可见面色苍白,但营养状良好,体重8.6kg,身长73cm。实验室检查:小细胞低色素性贫血(Hb8g/dl,网织红细胞0.1%)。白细胞为2700/μl,嗜中性白细胞8%。血清铁16μg/dl。血清维生素B_(12)和叶酸正常。G-6-PD和Hb电泳正常。骨髓可见有空泡的晚幼粒细胞和正成红细胞,髓细胞系统成熟受抑制。血清铜在11～30μg/dl之间(正常为80～110μg/dl)。血清铜蓝蛋白在11～25光密度单位(ODu)之间(正 Premature infants fed with low copper milk and those with copper deficiency due to severe diarrhea, malabsorption, protein loss, or complete parental parenteral nutrition without supplementation with copper are reported. Copper deficiency can cause anemia and other elusive symptoms, with a rich diet can eliminate, it is not easy to diagnose. EXAMPLE 1 A 6-month-old Arab baby boy admitted to hospital for vomiting and sluggishness, weighing 3500g, was born with milk only after birth. She was pale and well-nourished with a weight of 8.6kg and a length of 73cm. Laboratory tests: Small cell hypochromic anemia (Hb8g / dl, reticulocytes 0.1%). Leukocytes 2700 / μl, neutrophils 8%. Serum iron 16μg / dl. Serum vitamin B_ (12) and folic acid normal. G-6-PD and Hb electrophoresis normal. Bone marrow can be seen with vacuolar late promyelocytes and erythrocytes, myeloid system is inhibited by maturation. Serum copper in the 11 ~ 30μg / dl between (normally 80 ~ 110μg / dl). Serum ceruloplasmin is between 11 and 25 optical density units (ODu) (positive