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Kisspeptin是KiSS-1基因编码的一组多肽激素,与受体GPR54一起组成KiSS-1/GPR54系统,参与下丘脑-垂体-性腺轴功能的调节,并在青春期启动和促性腺素释放过程中发挥非常重要的作用。本文主要对KiSS-1/GPR54系统的分子结构,信号转导途径及对性腺轴功能的调节进行介绍。
Kisspeptin, a group of polypeptide hormones encoded by KiSS-1 gene, forms the KiSS-1 / GPR54 system together with the receptor GPR54 and is involved in the regulation of hypothalamic-pituitary-gonadal axis function and plays a role in puberty initiation and gonadotropin releasing process Very important role. In this paper, the molecular structure of KiSS-1 / GPR54 system, signal transduction pathway and regulation of gonadal axis function are introduced.