Seismic gap method is one of the effective earthquake prediction methods using seismicity patterns. However, this method has some limitations and uncertainty when using it singly in predicting earthquakes. This paper puts forward the prediction method using the dynamic seismicity pattern with dynamic implications. This method considers the formation and evolution of the seismic gap on the basis of plate movement and structural characteristics. Through analysis of 26 cases of earthquakes of Ms ≥ 5. 0 occurring in East China and South China, this paper obtains the relationship between the main shock with seismic gap and active fault＇s location, as well as the relationship between the seismic gap and location and strike of active faults. Meanwhile, this paper provides a dynamic explanation of the differences in the formation and evolution patterns of the seismic gap between the two regions, thus providing the physical basis for and reducing the uncertainty of predicting earthquakes using the seismic gap method.