氧化亚氮广泛用于外科麻醉和牙科镇痛。尽管该药历史悠久,效果良好,但它消除焦虑,解除疼痛的机制却不甚清楚。1979年Berkowitz 等发现,氧化亚氮的镇痛作用可能部分地与激动中枢神经系统中的内源性镇痛系统有关,即可能通过释放阿片样肽激动阿片受体。在动物和人体内均发现,阿片受体阻断剂纳 Nitrous oxide is widely used in surgical anesthesia and dental pain relief. Although the drug has a long history and works well, its mechanism to eliminate anxiety and relieve pain is not clear. In 1979, Berkowitz et al. Found that the analgesic effect of nitrous oxide may be partly related to the activation of the endogenous analgesic system in the central nervous system, which may activate opioid receptors by releasing opioid peptides. In both animals and humans, opioid receptor blockers were found