本文首次采用不同硒水平的人工合成饲料喂养大白鼠,观察到其胶原的变化与血硒呈正相关关系,尤以实验30天尿羟脯氨酸排出量为著(r=0.5454 P<0.01)。据此认为低硒确能影响胶原代谢,致尿羟脯氨酸排出减少。动物实验结果与大骨节病患儿尿羟脯氨酸改变相似,提示大骨节病致病因素可能与低硒有关。 In this paper, the rats fed with synthetic feed containing different levels of selenium for the first time showed that there was a positive correlation between changes of collagen and blood selenium, especially the level of urinary hydroxyproline after 30 days (r = 0.5454 P <0.01). According to that low selenium can indeed affect collagen metabolism, reducing urinary hydroxyproline emissions. Animal experiments and children with Kashin-Beck disease urinary hydroxyproline changes are similar, suggesting that the pathogenesis of Kashin-Beck disease may be related to low selenium.