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目的探讨喘安片联合富马酸酮替芬片治疗咳嗽变异性哮喘的临床疗效。方法选取武警宁夏总队医院2010年11月—2013年11月呼吸科门诊收治的咳嗽变异性哮喘患者126例,随机分为治疗组和对照组,各63例。治疗组给予喘安片联合富马酸酮替芬片治疗,对照组给予富马酸酮替芬片治疗。两组患者均加用雷诺考特鼻雾剂治疗鼻炎。比较两组患者的疗效、症状改善时间、症状消失时间及不良反应发生情况。结果治疗组总有效率高于对照组,咳嗽症状改善及完全消失时间短于对照组,差异有统计学意义(P<0.05)。治疗组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论喘安片联合酮替芬能快速缓解咳嗽症状,疗效确切、反复少,不良反应少,可作为治疗咳嗽变异性哮喘的方法之一。
Objective To investigate the clinical efficacy of Chuanan Tablets combined with ketotifen fumarate tablets in the treatment of cough variant asthma. Methods A total of 126 patients with cough variant asthma admitted to the Respiratory Clinic from November 2010 to November 2013 in Ningxia Corps Hospital were selected and randomly divided into treatment group and control group, with 63 cases in each group. The treatment group received Chuanan tablets combined with ketotifen fumarate tablets, while the control group was treated with ketotifen fumarate tablets. Both groups were treated with Renault test nasal spray rhinitis. The curative effect, symptom improvement time, symptom disappearance time and adverse reaction were compared between the two groups. Results The total effective rate of the treatment group was higher than that of the control group, and the improvement of cough symptoms and complete disappearance time were shorter than that of the control group (P <0.05). The incidence of adverse reactions in the treatment group was lower than that in the control group, the difference was statistically significant (P <0.05). Conclusions Chuan An Tablet combined with ketotifen can quickly relieve the symptoms of cough with definite curative effect, little repetition and few adverse reactions. It can be used as one of the methods to treat cough variant asthma.