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目的 :探讨肾福康胶囊对慢性肾炎和慢性肾功能不全的效应。方法 :观察肾福康胶囊对静脉注射小牛血清所致实验性大鼠肾炎 ,大部分肾切除术引起的肾衰和二硝基氯苯所致的迟发型超敏反应的药理作用。结果 :肾福康胶囊具有明显减少血清病型肾炎 (C- BSA) ,慢性肾功能不全大鼠尿蛋白 ,血清肌酐及尿素氮的作用 (分别为 P <0 .0 5 ,P <0 .0 1,P <0 .0 1) ,并可明显降低 C- BSA大鼠血清肌酐和减小肾小球直径 (分别为 P <0 .0 1,P <0 .0 5 )。对肾小球细胞增生和小鼠迟发型超敏反应亦有显著的抑制作用 (均为 P <0 .0 5 )。结论 :肾福康胶囊对实验性大鼠血清病型肾炎和慢性肾功能不全具有较好的疗效
Objective: To explore the effect of Shenfukang capsule on chronic nephritis and chronic renal insufficiency. METHODS: The pharmacological effects of Shenfukang capsule on experimental rat nephritis induced by intravenous injection of calf serum, renal failure caused by nephrectomy, and delayed type hypersensitivity reaction induced by dinitrochlorobenzene were observed. RESULTS: Shenfukang capsules significantly reduced urinary protein, serum creatinine and urea nitrogen in rats with serum-typed nephritis (C-BSA) and chronic renal insufficiency (P < 0.05, P <0. 1, P <0. 0 1), and can significantly reduce serum creatinine and glomerular diameter in C-BSA rats (P <0.01, P <0.05, respectively). There was also significant inhibition of glomerular cell proliferation and delayed type hypersensitivity in mice (all P < 0.05). Conclusion: Shenfukang capsule has good curative effect on experimental rat serum nephritis and chronic renal insufficiency