目的 :检测多形性腺瘤中BMP蛋白的表达及BMP2mRNA的扩增情况 ,以探讨多形性腺瘤的病理发生机制。方法 :应用BMP的单克隆抗体检测BMP在多形性腺瘤中的表达 ,并进一步应用BMP2的特异性引物和RT PCR的方法 ,扩增 6例多形性腺瘤组织中的RNA。结果 :6例多形性腺瘤组织中可以检测到BMP蛋白的扩增 ,其中 5例有BMP2mRNA的扩增。结论 :BMP可能参与了多形性腺瘤的病理机制 ,BMP的存在可能是上皮性肿瘤中类骨组织出现的重要因素。 Objective: To detect the expression of BMP protein and BMP2 mRNA in pleomorphic adenoma, so as to explore the pathological mechanism of pleomorphic adenoma. Methods: BMP was used to detect the expression of BMP in pleomorphic adenoma. BMP2 specific primers and RT PCR were used to amplify RNA in 6 pleomorphic adenomas. Results: The amplification of BMP protein was detected in 6 pleomorphic adenoma tissues, including 5 cases of BMP2 mRNA amplification. Conclusion: BMP may be involved in the pathogenesis of pleomorphic adenoma. The presence of BMP may be an important factor in the appearance of osteoid in epithelial tumors.