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目的探讨糖尿病与口腔扁平苔藓(OLP)的相关性。方法应用国内外数据库检索相关文献,将纳入文献分为A、B两组:A组是OLP患者中糖尿病患病为结局指标的文献;B组是糖尿病患者中OLP患病为结局指标的文献。采用RevMan5.1软件分别对A、B组相关数据进行Meta分析,评价糖尿病与OLP之间的相关性。结果共纳入15项研究,其中A组8项研究,病例1123例,正常对照1292例;B组7项研究,病例3652例,正常对照2618例。A组糖尿病患病合并OR值及95%CI为1.83(1.24,2.69),OLP组糖尿病患病率明显高于对照组,且差异有统计学意义(P=0.0002);B组OLP患病合并OR值及95%CI为2.25(1.34,3.78),糖尿病组OLP的患病率明显高于对照组,且差异有统计学意义(P=0.002)。结论糖尿病与OLP之间存在明显关联。在治疗OLP时需关注患者是否患有糖尿病,同期治疗糖尿病对OLP的疗效有重要作用。对于糖尿病患者,加强口腔宣教,定期进行口腔检查,及时发现并治疗OLP十分必要。
Objective To investigate the relationship between diabetes and oral lichen planus (OLP). Methods The related literatures about database retrieval in China and abroad were used, and the included articles were divided into A and B groups. Group A was the literature of the prevalence of diabetes mellitus in OLP patients. Group B was the literature of OLP prevalence in diabetic patients. RevMan5.1 software was used to analyze the data of group A and group B respectively to evaluate the correlation between diabetes and OLP. Results A total of 15 studies were included, of which 8 studies in group A, 1123 cases and 1292 cases in normal control group; 7 cases in group B, 3652 cases and 2618 normal controls. The prevalence of diabetes mellitus in group A was significantly higher than that in control group (95% CI: 1.83, 1.83, 1.64, 2.79), the difference was statistically significant (P = 0.0002) The OR and 95% CI were 2.25 (1.34, 3.78). The prevalence of OLP in diabetic group was significantly higher than that in control group, and the difference was statistically significant (P = 0.002). Conclusion There is a clear correlation between diabetes and OLP. In the treatment of OLP need to be concerned about whether patients with diabetes mellitus, the same period the treatment of diabetes on the efficacy of OLP has an important role. For diabetic patients, to strengthen oral education, regular oral examination, timely detection and treatment of OLP is necessary.