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目的:评价肝动脉介入化疗栓塞(TACE)合并三维适形放疗(3-DCRT)方法治疗中晚期肝癌的临床疗效。方法:收集2005-2010年122例在我院临床就诊的中晚期肝癌患者.将他们分为单纯介入和联合介入两组.平均每组61例。单纯介入组患者采用介入化疗栓塞的方法进行治疗;联合介入组患者采用介入化疗栓塞与放疗联合的方法进行治疗。对两组患者的临柬治疗效果、并发症和不良反应情况进行比较。结果:联合介入组患者的中位生存时同明显长于单纯介入组患者.有显著的统计学差异(P<0.05);该组患者治疗后半年和一年内的生存率明显高于单纯介入组.有显著的统计学差异(P<0.05);两组患者在治疗的过程中均出现了骨髓抑制等不良反应和并发症现象。但人数基本相同.没有显著的统计学差异(P>0.05)。结论:采用介入化疗栓塞与放疗联合的方法进行中晚期肝癌治疗的临床效果十分明显.可以使患者中位存活时同显著提高,使该病患者在半年和一年内的存活率显著提高.可以作为今后临床对该类患者进行治疗的首选方法。
Objective: To evaluate the clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with three-dimensional conformal radiotherapy (3-DCRT) in the treatment of advanced liver cancer. Methods: A total of 122 patients with advanced hepatocellular carcinoma (HCC) treated clinically in our hospital from 2005 to 2010 were divided into two groups: intervention group and intervention group, averaging 61 patients in each group. Patients in the interventional group were treated with interventional chemotherapy and embolization. Patients in the interventional group were treated with interventional chemotherapy and embolization combined with radiotherapy. The clinical efficacy, complications and adverse reactions of two groups of patients were compared. Results: The median survival time in the intervention group was significantly longer than that in the intervention group only (P <0.05). The survival rates in the six months and one year after treatment in the intervention group were significantly higher than those in the intervention group. There was a significant statistical difference (P <0.05). Both groups experienced adverse reactions such as myelosuppression and complications during the treatment. But the number is basically the same, there is no significant statistical difference (P> 0.05). Conclusion: The interventional chemotherapy with embolization combined with radiotherapy in the treatment of advanced liver cancer clinical effect is very obvious. Can make patients with median survival was significantly improved, so that patients with disease in six months and one year survival rate was significantly increased .As The preferred method of clinical treatment of such patients in the future.