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目的探讨术前吸烟对食管鳞癌生存期的影响。方法通过问卷调查、电话随访和住院病理结果核查。采用t检验和Spearman相关分析吸烟与食管鳞癌发生的关系,Kaplan-Meier生存曲线、Log rank检验、Cox回归评估影响患者生存期的独立因素。结果吸烟患者平均发病年龄明显高于不吸烟患者(P=0.02),开始吸烟年龄与发病年龄呈正相关(r=0.474,P<0.001);不吸烟患者的生存期优于吸烟患者(P<0.001),然而男性吸烟与不吸烟患者的生存期差异无统计学意义(P=0.245),并且不吸烟患者中女性患者的生存期明显优于男性(P<0.001);Cox回归分析提示吸烟不是影响食管鳞癌患者生存期的独立因素。结论食管鳞癌患者发病年龄与开始吸烟年龄高度相关;术前吸烟对食管鳞癌患者的生存期无明显影响。
Objective To investigate the effect of preoperative smoking on the survival of esophageal squamous cell carcinoma. Methods By questionnaire survey, telephone follow-up and in-hospital pathology results check. The relationship between smoking and esophageal squamous cell carcinoma was analyzed by t-test and Spearman correlation analysis. Kaplan-Meier survival curves, Log rank test and Cox regression were used to evaluate the independent factors affecting the survival of patients. Results The average age at onset of smoking was significantly higher in non-smokers than in smokers (P = 0.02). The age at onset of smokers was positively correlated with the age of onset (r = 0.474, P <0.001) ). However, there was no significant difference in survival between male and non-smokers (P = 0.245), and the survival of female patients was significantly better than male (P <0.001) in non-smokers. Cox regression analysis indicated that smoking did not affect Esophageal squamous cell carcinoma survival independent factors. Conclusion The age of onset of esophageal squamous cell carcinoma is highly correlated with the age at onset of smoking. Preoperative smoking has no significant effect on the survival of patients with esophageal squamous cell carcinoma.