多发性骨髓瘤(multiple myeloma,MM)是浆细胞的恶性肿瘤,分泌单克隆的免疫球蛋白,临床上主要以贫血、骨痛、肾功能损害,反复感染和高钙血症为主要表现,我院收治了1例以肝大、阻塞性黄疸为首发表现的极其少见的多发性骨髓瘤,现报道如下。1临床资料患者,女,43岁,因“腹胀10余天”入院。查体:重度贫血貌,皮肤巩膜黄染,全身浅表淋巴结未及肿大,心肺无特殊,腹软,无压痛及反跳痛,肝右肋下10cm可扪及,质中,无压痛,脾 Multiple myeloma (MM) is a malignant tumor of plasma cells that secrete monoclonal immunoglobulin. Mainly clinical anemia, bone pain, renal dysfunction, recurrent infection and hypercalcemia are the main manifestations of myeloma Hospital admitted 1 case of hepatomegaly, obstructive jaundice as the first manifestation of an extremely rare multiple myeloma, are reported below. 1 clinical data patients, female, 43 years old, due to “bloating more than 10 days ” admission. Physical examination: severe anemia appearance, skin scleral yellow dye, systemic superficial lymph nodes without swelling, no special cardiopulmonary, abdominal soft, no tenderness and rebound tenderness, palpable 10cm under the right rib, palpable mass, no tenderness, spleen