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目的探讨呼出气一氧化氮(FeNO)监测对慢性咳嗽经验性应用糖皮质激素治疗的指导价值。方法 118例慢性咳嗽患者口服泼尼松0.5mg/kg治疗1周,检测治疗前后FeNO水平,并分析FeNO水平与激素治疗有效性的关系。结果激素治疗有效患者治疗前的FeNO水平高于治疗无效患者[(65.05±49.15)ppb vs.(30.07±8.22)ppb](P<0.05);激素治疗后,治疗有效患者的FeNO水平下降(48.83±19.07)%,高于治疗无效患者的(1.80±17.61)%(P<0.05)。判断激素治疗有效的FeNO最佳临界值为37.90ppb,敏感度为82.14%,特异度为85.48%。结论 FeNO水平对慢性咳嗽经验性应用激素治疗的有效性具有预测作用。
Objective To investigate the clinical value of exhaled nitric oxide (FeNO) monitoring in the empirical application of glucocorticoid therapy for chronic cough. Methods One hundred and thirteen patients with chronic cough were treated with prednisone 0.5 mg / kg for 1 week. The levels of FeNO before and after treatment were measured. The relationship between FeNO levels and the effectiveness of hormone therapy was analyzed. Results The levels of FeNO in patients with active hormone therapy before treatment were significantly higher than those in patients with ineffective therapy ([(65.05 ± 49.15) ppb vs. (30.07 ± 8.22) ppb] (P <0.05) ± 19.07%, higher than that in patients with ineffective treatment (1.80 ± 17.61)% (P <0.05). The optimal threshold of FeNO for hormone therapy was 37.90ppb, the sensitivity was 82.14% and the specificity was 85.48%. Conclusion FeNO level has predictive value for the empirical application of hormonal therapy in chronic cough.