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目的探讨超敏C反应蛋白在原发性肾病综合征患儿病变中的临床意义。方法采用免疫层析法对100例原发性肾病综合征患儿和100例健康儿童的超敏C反应蛋白(hs-CRP)进行检测。结果病例组患儿Scr,BUN和hs-CRP均明显高于对照组,差异均有统计学意义(P﹤0.05),hs-CRP和Scr呈显著的正相关(r=0.667,P﹤0.01);hs-CRP与Scr呈显著的正相关(r=0.686,P﹤0.01),治疗后Scr,BUN和hs-CRPde均明显低于对照组,差异均有统计学意义(P﹤0.05)。结论原发性肾病综合征患儿检查hs-CRP明确诊断,并且可以判断病情的严重程度,反映治疗效果。
Objective To investigate the clinical significance of high sensitivity C-reactive protein in children with primary nephrotic syndrome. Methods Immunochromatography was used to detect hs-CRP in 100 children with primary nephrotic syndrome and 100 healthy children. Results The levels of Scr, BUN and hs-CRP in case group were significantly higher than those in control group (P <0.05), while there was a significant positive correlation between hs-CRP and Scr (r = 0.667, P <0.01) ; There was a significant positive correlation between hs-CRP and Scr (r = 0.686, P <0.01). Scr, BUN and hs-CRPde were significantly lower than those of the control group after treatment, the difference was statistically significant (P <0.05). Conclusion The diagnosis of primary nephrotic syndrome in children with hs-CRP diagnosis, and can determine the severity of the disease, reflecting the therapeutic effect.